Adjuvant radiotherapy with brachytherapy boost in soft tissue sarcomas
Identifieur interne : 000800 ( Main/Exploration ); précédent : 000799; suivant : 000801Adjuvant radiotherapy with brachytherapy boost in soft tissue sarcomas
Auteurs : Annalisa Cortesi ; Andrea Galuppi ; Rezarta Frakulli ; Alessandra Arcelli ; Fabrizio Romani ; Gian Carlo Mattiucci [Italie] ; Giuseppe Bianchi ; Stefano Ferrari ; Andrea Ferraro ; Andrea Farioli ; Marco Gambarotti ; Alberto Righi ; Gabriella Macchia ; Francesco Deodato ; Savino Cilla [Italie] ; Milly Buwenge ; Vincenzo Valentini [Italie] ; Alessio Giuseppe Morganti ; Davide Donati ; Silvia CammelliSource :
- Journal of Contemporary Brachytherapy [ 1689-832X ] ; 2017.
Abstract
The standard primary treatment for soft tissue sarcoma (STS) is a wide surgical resection, preceded or followed by radiotherapy. Purpose of this retrospective study was to assess the efficacy of perioperative brachytherapy (BRT) plus postoperative external beam radiation therapy (EBRT) in patients with intermediate-high risk STS.
BRT delivered dose was 20 Gy. External beam radiation therapy was delivered with 3D-technique using multiple beams. The prescribed dose was 46 Gy to the PTV. Neoadjuvant and adjuvant chemotherapy (CHT) was used in patients with potentially chemosensitive histological subtypes. The primary aim of the study was to analyze overall survival (OS) and local control (LC) in a large patient population treated with surgery, perioperative BRT, and adjuvant EBRT ± CHT. Secondary objective was to identify prognostic factors for patients outcome in terms of LC, disease-free survival (DFS), and OS.
From 2000 to 2011, 107 patients presenting 2-3 grade (FNLCC) primary or recurrent STS were treated with surgery, perioperative BRT, and adjuvant EBRT ± CHT. Five-year LC and OS were 80.9% and 87.4%, respectively. At univariate analysis, a higher LC was recorded in primary vs. recurrent tumors (
The combination of BRT and EBRT was able to achieve satisfactory results even in a patients population with intermediate-high risk STS. Patients with recurrent or other than lower limb sited tumors show a worse LC.
Url:
DOI: 10.5114/jcb.2017.68215
PubMed: 28725250
PubMed Central: 5509983
Affiliations:
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Adjuvant radiotherapy with brachytherapy boost in soft tissue sarcomas</title><author><name sortKey="Cortesi, Annalisa" sort="Cortesi, Annalisa" uniqKey="Cortesi A" first="Annalisa" last="Cortesi">Annalisa Cortesi</name><affiliation><nlm:aff id="aff0001">Radiation Oncology Unit, Department of Experimental, Diagnostic and Specialty Medicine – DIMES, University of Bologna, S. Orsola-Malpighi Hospital, Bologna</nlm:aff><wicri:noCountry code="subfield">Bologna</wicri:noCountry></affiliation></author><author><name sortKey="Galuppi, Andrea" sort="Galuppi, Andrea" uniqKey="Galuppi A" first="Andrea" last="Galuppi">Andrea Galuppi</name><affiliation><nlm:aff id="aff0001">Radiation Oncology Unit, Department of Experimental, Diagnostic and Specialty Medicine – DIMES, University of Bologna, S. Orsola-Malpighi Hospital, Bologna</nlm:aff><wicri:noCountry code="subfield">Bologna</wicri:noCountry></affiliation></author><author><name sortKey="Frakulli, Rezarta" sort="Frakulli, Rezarta" uniqKey="Frakulli R" first="Rezarta" last="Frakulli">Rezarta Frakulli</name><affiliation><nlm:aff id="aff0001">Radiation Oncology Unit, Department of Experimental, Diagnostic and Specialty Medicine – DIMES, University of Bologna, S. Orsola-Malpighi Hospital, Bologna</nlm:aff><wicri:noCountry code="subfield">Bologna</wicri:noCountry></affiliation></author><author><name sortKey="Arcelli, Alessandra" sort="Arcelli, Alessandra" uniqKey="Arcelli A" first="Alessandra" last="Arcelli">Alessandra Arcelli</name><affiliation><nlm:aff id="aff0001">Radiation Oncology Unit, Department of Experimental, Diagnostic and Specialty Medicine – DIMES, University of Bologna, S. Orsola-Malpighi Hospital, Bologna</nlm:aff><wicri:noCountry code="subfield">Bologna</wicri:noCountry></affiliation></author><author><name sortKey="Romani, Fabrizio" sort="Romani, Fabrizio" uniqKey="Romani F" first="Fabrizio" last="Romani">Fabrizio Romani</name><affiliation><nlm:aff id="aff0002">Medical Physic Unit, Policlinico S. Orsola-Maplighi, Bologna</nlm:aff><wicri:noCountry code="subfield">Bologna</wicri:noCountry></affiliation></author><author><name sortKey="Mattiucci, Gian Carlo" sort="Mattiucci, Gian Carlo" uniqKey="Mattiucci G" first="Gian Carlo" last="Mattiucci">Gian Carlo Mattiucci</name><affiliation wicri:level="3"><nlm:aff id="aff0003">Department of Radiotherapy, Policlinico Universitario “A. Gemelli”, Università Cattolica del Sacro Cuore, Rome</nlm:aff><country>Italie</country><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName><wicri:orgArea>Department of Radiotherapy, Policlinico Universitario “A. Gemelli”, Università Cattolica del Sacro Cuore</wicri:orgArea></affiliation></author><author><name sortKey="Bianchi, Giuseppe" sort="Bianchi, Giuseppe" uniqKey="Bianchi G" first="Giuseppe" last="Bianchi">Giuseppe Bianchi</name><affiliation><nlm:aff id="aff0004">Clinica Ortopedica, Istituto Ortopedico Rizzoli, Via Pupilli 1, Bologna</nlm:aff><wicri:noCountry code="subfield">Bologna</wicri:noCountry></affiliation></author><author><name sortKey="Ferrari, Stefano" sort="Ferrari, Stefano" uniqKey="Ferrari S" first="Stefano" last="Ferrari">Stefano Ferrari</name><affiliation><nlm:aff id="aff0005">Department of Oncology, Rizzoli Institute, Bologna</nlm:aff><wicri:noCountry code="subfield">Bologna</wicri:noCountry></affiliation></author><author><name sortKey="Ferraro, Andrea" sort="Ferraro, Andrea" uniqKey="Ferraro A" first="Andrea" last="Ferraro">Andrea Ferraro</name><affiliation><nlm:aff id="aff0004">Clinica Ortopedica, Istituto Ortopedico Rizzoli, Via Pupilli 1, Bologna</nlm:aff><wicri:noCountry code="subfield">Bologna</wicri:noCountry></affiliation></author><author><name sortKey="Farioli, Andrea" sort="Farioli, Andrea" uniqKey="Farioli A" first="Andrea" last="Farioli">Andrea Farioli</name><affiliation><nlm:aff id="aff0006">Department of Medical and Surgical Sciences (DIMEC), University of Bologna, S. Orsola-Malpighi Hospital, Bologna</nlm:aff><wicri:noCountry code="subfield">Bologna</wicri:noCountry></affiliation></author><author><name sortKey="Gambarotti, Marco" sort="Gambarotti, Marco" uniqKey="Gambarotti M" first="Marco" last="Gambarotti">Marco Gambarotti</name><affiliation><nlm:aff id="aff0007">Department of Pathology, Istituto Ortopedico Rizzoli, Via Pupilli 1, Bologna</nlm:aff><wicri:noCountry code="subfield">Bologna</wicri:noCountry></affiliation></author><author><name sortKey="Righi, Alberto" sort="Righi, Alberto" uniqKey="Righi A" first="Alberto" last="Righi">Alberto Righi</name><affiliation><nlm:aff id="aff0007">Department of Pathology, Istituto Ortopedico Rizzoli, Via Pupilli 1, Bologna</nlm:aff><wicri:noCountry code="subfield">Bologna</wicri:noCountry></affiliation></author><author><name sortKey="Macchia, Gabriella" sort="Macchia, Gabriella" uniqKey="Macchia G" first="Gabriella" last="Macchia">Gabriella Macchia</name><affiliation><nlm:aff id="aff0008">Radiotherapy Unit, Fondazione di Ricerca e Cura “Giovanni Paolo II”, Catholic University of Sacred Heart, Campobasso</nlm:aff><wicri:noCountry code="subfield">Campobasso</wicri:noCountry></affiliation></author><author><name sortKey="Deodato, Francesco" sort="Deodato, Francesco" uniqKey="Deodato F" first="Francesco" last="Deodato">Francesco Deodato</name><affiliation><nlm:aff id="aff0008">Radiotherapy Unit, Fondazione di Ricerca e Cura “Giovanni Paolo II”, Catholic University of Sacred Heart, Campobasso</nlm:aff><wicri:noCountry code="subfield">Campobasso</wicri:noCountry></affiliation></author><author><name sortKey="Cilla, Savino" sort="Cilla, Savino" uniqKey="Cilla S" first="Savino" last="Cilla">Savino Cilla</name><affiliation wicri:level="1"><nlm:aff id="aff0009">Medical Physic Unit, Fondazione di Ricerca e Cura “Giovanni Paolo II”, Catholic University of Sacred Heart, Campobasso, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Medical Physic Unit, Fondazione di Ricerca e Cura “Giovanni Paolo II”, Catholic University of Sacred Heart, Campobasso</wicri:regionArea><wicri:noRegion>Campobasso</wicri:noRegion></affiliation></author><author><name sortKey="Buwenge, Milly" sort="Buwenge, Milly" uniqKey="Buwenge M" first="Milly" last="Buwenge">Milly Buwenge</name><affiliation><nlm:aff id="aff0001">Radiation Oncology Unit, Department of Experimental, Diagnostic and Specialty Medicine – DIMES, University of Bologna, S. Orsola-Malpighi Hospital, Bologna</nlm:aff><wicri:noCountry code="subfield">Bologna</wicri:noCountry></affiliation></author><author><name sortKey="Valentini, Vincenzo" sort="Valentini, Vincenzo" uniqKey="Valentini V" first="Vincenzo" last="Valentini">Vincenzo Valentini</name><affiliation wicri:level="3"><nlm:aff id="aff0003">Department of Radiotherapy, Policlinico Universitario “A. Gemelli”, Università Cattolica del Sacro Cuore, Rome</nlm:aff><country>Italie</country><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName><wicri:orgArea>Department of Radiotherapy, Policlinico Universitario “A. Gemelli”, Università Cattolica del Sacro Cuore</wicri:orgArea></affiliation></author><author><name sortKey="Morganti, Alessio Giuseppe" sort="Morganti, Alessio Giuseppe" uniqKey="Morganti A" first="Alessio Giuseppe" last="Morganti">Alessio Giuseppe Morganti</name><affiliation><nlm:aff id="aff0001">Radiation Oncology Unit, Department of Experimental, Diagnostic and Specialty Medicine – DIMES, University of Bologna, S. Orsola-Malpighi Hospital, Bologna</nlm:aff><wicri:noCountry code="subfield">Bologna</wicri:noCountry></affiliation></author><author><name sortKey="Donati, Davide" sort="Donati, Davide" uniqKey="Donati D" first="Davide" last="Donati">Davide Donati</name><affiliation><nlm:aff id="aff0004">Clinica Ortopedica, Istituto Ortopedico Rizzoli, Via Pupilli 1, Bologna</nlm:aff><wicri:noCountry code="subfield">Bologna</wicri:noCountry></affiliation></author><author><name sortKey="Cammelli, Silvia" sort="Cammelli, Silvia" uniqKey="Cammelli S" first="Silvia" last="Cammelli">Silvia Cammelli</name><affiliation><nlm:aff id="aff0001">Radiation Oncology Unit, Department of Experimental, Diagnostic and Specialty Medicine – DIMES, University of Bologna, S. Orsola-Malpighi Hospital, Bologna</nlm:aff><wicri:noCountry code="subfield">Bologna</wicri:noCountry></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">28725250</idno><idno type="pmc">5509983</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5509983</idno><idno type="RBID">PMC:5509983</idno><idno type="doi">10.5114/jcb.2017.68215</idno><date when="2017">2017</date><idno type="wicri:Area/Pmc/Corpus">004051</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">004051</idno><idno type="wicri:Area/Pmc/Curation">004050</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">004050</idno><idno type="wicri:Area/Pmc/Checkpoint">000403</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000403</idno><idno type="wicri:Area/Ncbi/Merge">009294</idno><idno type="wicri:Area/Ncbi/Curation">009294</idno><idno type="wicri:Area/Ncbi/Checkpoint">009294</idno><idno type="wicri:doubleKey">1689-832X:2017:Cortesi A:adjuvant:radiotherapy:with</idno><idno type="wicri:Area/Main/Merge">000801</idno><idno type="wicri:Area/Main/Curation">000800</idno><idno type="wicri:Area/Main/Exploration">000800</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Adjuvant radiotherapy with brachytherapy boost in soft tissue sarcomas</title><author><name sortKey="Cortesi, Annalisa" sort="Cortesi, Annalisa" uniqKey="Cortesi A" first="Annalisa" last="Cortesi">Annalisa Cortesi</name><affiliation><nlm:aff id="aff0001">Radiation Oncology Unit, Department of Experimental, Diagnostic and Specialty Medicine – DIMES, University of Bologna, S. Orsola-Malpighi Hospital, Bologna</nlm:aff><wicri:noCountry code="subfield">Bologna</wicri:noCountry></affiliation></author><author><name sortKey="Galuppi, Andrea" sort="Galuppi, Andrea" uniqKey="Galuppi A" first="Andrea" last="Galuppi">Andrea Galuppi</name><affiliation><nlm:aff id="aff0001">Radiation Oncology Unit, Department of Experimental, Diagnostic and Specialty Medicine – DIMES, University of Bologna, S. Orsola-Malpighi Hospital, Bologna</nlm:aff><wicri:noCountry code="subfield">Bologna</wicri:noCountry></affiliation></author><author><name sortKey="Frakulli, Rezarta" sort="Frakulli, Rezarta" uniqKey="Frakulli R" first="Rezarta" last="Frakulli">Rezarta Frakulli</name><affiliation><nlm:aff id="aff0001">Radiation Oncology Unit, Department of Experimental, Diagnostic and Specialty Medicine – DIMES, University of Bologna, S. Orsola-Malpighi Hospital, Bologna</nlm:aff><wicri:noCountry code="subfield">Bologna</wicri:noCountry></affiliation></author><author><name sortKey="Arcelli, Alessandra" sort="Arcelli, Alessandra" uniqKey="Arcelli A" first="Alessandra" last="Arcelli">Alessandra Arcelli</name><affiliation><nlm:aff id="aff0001">Radiation Oncology Unit, Department of Experimental, Diagnostic and Specialty Medicine – DIMES, University of Bologna, S. Orsola-Malpighi Hospital, Bologna</nlm:aff><wicri:noCountry code="subfield">Bologna</wicri:noCountry></affiliation></author><author><name sortKey="Romani, Fabrizio" sort="Romani, Fabrizio" uniqKey="Romani F" first="Fabrizio" last="Romani">Fabrizio Romani</name><affiliation><nlm:aff id="aff0002">Medical Physic Unit, Policlinico S. Orsola-Maplighi, Bologna</nlm:aff><wicri:noCountry code="subfield">Bologna</wicri:noCountry></affiliation></author><author><name sortKey="Mattiucci, Gian Carlo" sort="Mattiucci, Gian Carlo" uniqKey="Mattiucci G" first="Gian Carlo" last="Mattiucci">Gian Carlo Mattiucci</name><affiliation wicri:level="3"><nlm:aff id="aff0003">Department of Radiotherapy, Policlinico Universitario “A. Gemelli”, Università Cattolica del Sacro Cuore, Rome</nlm:aff><country>Italie</country><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName><wicri:orgArea>Department of Radiotherapy, Policlinico Universitario “A. Gemelli”, Università Cattolica del Sacro Cuore</wicri:orgArea></affiliation></author><author><name sortKey="Bianchi, Giuseppe" sort="Bianchi, Giuseppe" uniqKey="Bianchi G" first="Giuseppe" last="Bianchi">Giuseppe Bianchi</name><affiliation><nlm:aff id="aff0004">Clinica Ortopedica, Istituto Ortopedico Rizzoli, Via Pupilli 1, Bologna</nlm:aff><wicri:noCountry code="subfield">Bologna</wicri:noCountry></affiliation></author><author><name sortKey="Ferrari, Stefano" sort="Ferrari, Stefano" uniqKey="Ferrari S" first="Stefano" last="Ferrari">Stefano Ferrari</name><affiliation><nlm:aff id="aff0005">Department of Oncology, Rizzoli Institute, Bologna</nlm:aff><wicri:noCountry code="subfield">Bologna</wicri:noCountry></affiliation></author><author><name sortKey="Ferraro, Andrea" sort="Ferraro, Andrea" uniqKey="Ferraro A" first="Andrea" last="Ferraro">Andrea Ferraro</name><affiliation><nlm:aff id="aff0004">Clinica Ortopedica, Istituto Ortopedico Rizzoli, Via Pupilli 1, Bologna</nlm:aff><wicri:noCountry code="subfield">Bologna</wicri:noCountry></affiliation></author><author><name sortKey="Farioli, Andrea" sort="Farioli, Andrea" uniqKey="Farioli A" first="Andrea" last="Farioli">Andrea Farioli</name><affiliation><nlm:aff id="aff0006">Department of Medical and Surgical Sciences (DIMEC), University of Bologna, S. Orsola-Malpighi Hospital, Bologna</nlm:aff><wicri:noCountry code="subfield">Bologna</wicri:noCountry></affiliation></author><author><name sortKey="Gambarotti, Marco" sort="Gambarotti, Marco" uniqKey="Gambarotti M" first="Marco" last="Gambarotti">Marco Gambarotti</name><affiliation><nlm:aff id="aff0007">Department of Pathology, Istituto Ortopedico Rizzoli, Via Pupilli 1, Bologna</nlm:aff><wicri:noCountry code="subfield">Bologna</wicri:noCountry></affiliation></author><author><name sortKey="Righi, Alberto" sort="Righi, Alberto" uniqKey="Righi A" first="Alberto" last="Righi">Alberto Righi</name><affiliation><nlm:aff id="aff0007">Department of Pathology, Istituto Ortopedico Rizzoli, Via Pupilli 1, Bologna</nlm:aff><wicri:noCountry code="subfield">Bologna</wicri:noCountry></affiliation></author><author><name sortKey="Macchia, Gabriella" sort="Macchia, Gabriella" uniqKey="Macchia G" first="Gabriella" last="Macchia">Gabriella Macchia</name><affiliation><nlm:aff id="aff0008">Radiotherapy Unit, Fondazione di Ricerca e Cura “Giovanni Paolo II”, Catholic University of Sacred Heart, Campobasso</nlm:aff><wicri:noCountry code="subfield">Campobasso</wicri:noCountry></affiliation></author><author><name sortKey="Deodato, Francesco" sort="Deodato, Francesco" uniqKey="Deodato F" first="Francesco" last="Deodato">Francesco Deodato</name><affiliation><nlm:aff id="aff0008">Radiotherapy Unit, Fondazione di Ricerca e Cura “Giovanni Paolo II”, Catholic University of Sacred Heart, Campobasso</nlm:aff><wicri:noCountry code="subfield">Campobasso</wicri:noCountry></affiliation></author><author><name sortKey="Cilla, Savino" sort="Cilla, Savino" uniqKey="Cilla S" first="Savino" last="Cilla">Savino Cilla</name><affiliation wicri:level="1"><nlm:aff id="aff0009">Medical Physic Unit, Fondazione di Ricerca e Cura “Giovanni Paolo II”, Catholic University of Sacred Heart, Campobasso, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Medical Physic Unit, Fondazione di Ricerca e Cura “Giovanni Paolo II”, Catholic University of Sacred Heart, Campobasso</wicri:regionArea><wicri:noRegion>Campobasso</wicri:noRegion></affiliation></author><author><name sortKey="Buwenge, Milly" sort="Buwenge, Milly" uniqKey="Buwenge M" first="Milly" last="Buwenge">Milly Buwenge</name><affiliation><nlm:aff id="aff0001">Radiation Oncology Unit, Department of Experimental, Diagnostic and Specialty Medicine – DIMES, University of Bologna, S. Orsola-Malpighi Hospital, Bologna</nlm:aff><wicri:noCountry code="subfield">Bologna</wicri:noCountry></affiliation></author><author><name sortKey="Valentini, Vincenzo" sort="Valentini, Vincenzo" uniqKey="Valentini V" first="Vincenzo" last="Valentini">Vincenzo Valentini</name><affiliation wicri:level="3"><nlm:aff id="aff0003">Department of Radiotherapy, Policlinico Universitario “A. Gemelli”, Università Cattolica del Sacro Cuore, Rome</nlm:aff><country>Italie</country><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName><wicri:orgArea>Department of Radiotherapy, Policlinico Universitario “A. Gemelli”, Università Cattolica del Sacro Cuore</wicri:orgArea></affiliation></author><author><name sortKey="Morganti, Alessio Giuseppe" sort="Morganti, Alessio Giuseppe" uniqKey="Morganti A" first="Alessio Giuseppe" last="Morganti">Alessio Giuseppe Morganti</name><affiliation><nlm:aff id="aff0001">Radiation Oncology Unit, Department of Experimental, Diagnostic and Specialty Medicine – DIMES, University of Bologna, S. Orsola-Malpighi Hospital, Bologna</nlm:aff><wicri:noCountry code="subfield">Bologna</wicri:noCountry></affiliation></author><author><name sortKey="Donati, Davide" sort="Donati, Davide" uniqKey="Donati D" first="Davide" last="Donati">Davide Donati</name><affiliation><nlm:aff id="aff0004">Clinica Ortopedica, Istituto Ortopedico Rizzoli, Via Pupilli 1, Bologna</nlm:aff><wicri:noCountry code="subfield">Bologna</wicri:noCountry></affiliation></author><author><name sortKey="Cammelli, Silvia" sort="Cammelli, Silvia" uniqKey="Cammelli S" first="Silvia" last="Cammelli">Silvia Cammelli</name><affiliation><nlm:aff id="aff0001">Radiation Oncology Unit, Department of Experimental, Diagnostic and Specialty Medicine – DIMES, University of Bologna, S. Orsola-Malpighi Hospital, Bologna</nlm:aff><wicri:noCountry code="subfield">Bologna</wicri:noCountry></affiliation></author></analytic><series><title level="j">Journal of Contemporary Brachytherapy</title><idno type="ISSN">1689-832X</idno><idno type="eISSN">2081-2841</idno><imprint><date when="2017">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec id="s1"><title>Purpose</title><p>The standard primary treatment for soft tissue sarcoma (STS) is a wide surgical resection, preceded or followed by radiotherapy. Purpose of this retrospective study was to assess the efficacy of perioperative brachytherapy (BRT) plus postoperative external beam radiation therapy (EBRT) in patients with intermediate-high risk STS.</p></sec><sec id="s2"><title>Material and methods</title><p>BRT delivered dose was 20 Gy. External beam radiation therapy was delivered with 3D-technique using multiple beams. The prescribed dose was 46 Gy to the PTV. Neoadjuvant and adjuvant chemotherapy (CHT) was used in patients with potentially chemosensitive histological subtypes. The primary aim of the study was to analyze overall survival (OS) and local control (LC) in a large patient population treated with surgery, perioperative BRT, and adjuvant EBRT ± CHT. Secondary objective was to identify prognostic factors for patients outcome in terms of LC, disease-free survival (DFS), and OS.</p></sec><sec id="s3"><title>Results</title><p>From 2000 to 2011, 107 patients presenting 2-3 grade (FNLCC) primary or recurrent STS were treated with surgery, perioperative BRT, and adjuvant EBRT ± CHT. Five-year LC and OS were 80.9% and 87.4%, respectively. At univariate analysis, a higher LC was recorded in primary vs. recurrent tumors (<italic>p</italic> = 0.015), and in lower limb tumors vs. other sites (<italic>p</italic> = 0.027). An improved DFS was recorded in patients with lower limb tumors vs. other sites (<italic>p</italic> = 0.034).</p></sec><sec id="s4"><title>Conclusions</title><p>The combination of BRT and EBRT was able to achieve satisfactory results even in a patients population with intermediate-high risk STS. Patients with recurrent or other than lower limb sited tumors show a worse LC.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Siegel, Rl" uniqKey="Siegel R">RL Siegel</name></author><author><name sortKey="Miller, Kd" uniqKey="Miller K">KD Miller</name></author><author><name sortKey="Jemal, A" uniqKey="Jemal A">A Jemal</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yang, Jc" uniqKey="Yang J">JC Yang</name></author><author><name sortKey="Chang, Ae" uniqKey="Chang A">AE Chang</name></author><author><name sortKey="Baker, Ar" uniqKey="Baker A">AR Baker</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jebsen, Nl" uniqKey="Jebsen N">NL Jebsen</name></author><author><name sortKey="Trovik, Cs" uniqKey="Trovik C">CS Trovik</name></author><author><name sortKey="Bauer, Hc" uniqKey="Bauer H">HC Bauer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rosenberg, Sa" uniqKey="Rosenberg S">SA Rosenberg</name></author><author><name sortKey="Tepper, J" uniqKey="Tepper J">J Tepper</name></author><author><name sortKey="Glatstein, E" uniqKey="Glatstein E">E Glatstein</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Delannes, M" uniqKey="Delannes M">M Delannes</name></author><author><name sortKey="Thomas, L" uniqKey="Thomas L">L Thomas</name></author><author><name sortKey="Martel, P" uniqKey="Martel P">P Martel</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Alektiar, Km" uniqKey="Alektiar K">KM Alektiar</name></author><author><name sortKey="Leung, D" uniqKey="Leung D">D Leung</name></author><author><name sortKey="Zelefsky, M" uniqKey="Zelefsky M">M Zelefsky</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lazzaro, G" uniqKey="Lazzaro G">G 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Lanciano</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mundt, Aj" uniqKey="Mundt A">AJ Mundt</name></author><author><name sortKey="Awan, A" uniqKey="Awan A">A Awan</name></author><author><name sortKey="Sibley, Gs" uniqKey="Sibley G">GS Sibley</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Italie</li></country><region><li>Latium</li></region><settlement><li>Rome</li></settlement></list><tree><noCountry><name sortKey="Arcelli, Alessandra" sort="Arcelli, Alessandra" uniqKey="Arcelli A" first="Alessandra" last="Arcelli">Alessandra Arcelli</name><name sortKey="Bianchi, Giuseppe" sort="Bianchi, Giuseppe" uniqKey="Bianchi G" first="Giuseppe" last="Bianchi">Giuseppe Bianchi</name><name sortKey="Buwenge, Milly" sort="Buwenge, Milly" uniqKey="Buwenge M" first="Milly" last="Buwenge">Milly Buwenge</name><name sortKey="Cammelli, Silvia" sort="Cammelli, Silvia" uniqKey="Cammelli S" first="Silvia" last="Cammelli">Silvia Cammelli</name><name sortKey="Cortesi, Annalisa" sort="Cortesi, Annalisa" uniqKey="Cortesi A" first="Annalisa" last="Cortesi">Annalisa Cortesi</name><name sortKey="Deodato, Francesco" sort="Deodato, Francesco" uniqKey="Deodato F" first="Francesco" last="Deodato">Francesco Deodato</name><name sortKey="Donati, Davide" sort="Donati, Davide" uniqKey="Donati D" first="Davide" last="Donati">Davide Donati</name><name sortKey="Farioli, Andrea" sort="Farioli, Andrea" uniqKey="Farioli A" first="Andrea" last="Farioli">Andrea Farioli</name><name sortKey="Ferrari, Stefano" sort="Ferrari, Stefano" uniqKey="Ferrari S" first="Stefano" last="Ferrari">Stefano Ferrari</name><name sortKey="Ferraro, Andrea" sort="Ferraro, Andrea" uniqKey="Ferraro A" first="Andrea" last="Ferraro">Andrea Ferraro</name><name sortKey="Frakulli, Rezarta" sort="Frakulli, Rezarta" uniqKey="Frakulli R" first="Rezarta" last="Frakulli">Rezarta Frakulli</name><name sortKey="Galuppi, Andrea" sort="Galuppi, Andrea" uniqKey="Galuppi A" first="Andrea" last="Galuppi">Andrea Galuppi</name><name sortKey="Gambarotti, Marco" sort="Gambarotti, Marco" uniqKey="Gambarotti M" first="Marco" last="Gambarotti">Marco Gambarotti</name><name sortKey="Macchia, Gabriella" sort="Macchia, Gabriella" uniqKey="Macchia G" first="Gabriella" last="Macchia">Gabriella Macchia</name><name sortKey="Morganti, Alessio Giuseppe" sort="Morganti, Alessio Giuseppe" uniqKey="Morganti A" first="Alessio Giuseppe" last="Morganti">Alessio Giuseppe Morganti</name><name sortKey="Righi, Alberto" sort="Righi, Alberto" uniqKey="Righi A" first="Alberto" last="Righi">Alberto Righi</name><name sortKey="Romani, Fabrizio" sort="Romani, Fabrizio" uniqKey="Romani F" first="Fabrizio" last="Romani">Fabrizio Romani</name></noCountry><country name="Italie"><region name="Latium"><name sortKey="Mattiucci, Gian Carlo" sort="Mattiucci, Gian Carlo" uniqKey="Mattiucci G" first="Gian Carlo" last="Mattiucci">Gian Carlo Mattiucci</name></region><name sortKey="Cilla, Savino" sort="Cilla, Savino" uniqKey="Cilla S" first="Savino" last="Cilla">Savino Cilla</name><name sortKey="Valentini, Vincenzo" sort="Valentini, Vincenzo" uniqKey="Valentini V" first="Vincenzo" last="Valentini">Vincenzo Valentini</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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